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KMID : 0043320100330081143
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Archives of Pharmacal Research
2010 Volume.33 No. 8 p.1143 ~ p.1148
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Baimantuoluosides D-G, four new withanolide glucosides from the flower of Datura metel L.
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Yang Bing-You
Xia Yong-Gang
Wang Qiu-hong
Dou De-qiang
Kuang Hai-Xue
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Abstract
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In our search for bioactive anti-psoriasis compounds from the flower of Datura metel L, we isolated four new withanolide glucosides, baimantuoluosides D, E, F and G (1?4). The structures of the new compounds are (5α,6α,7β,22R)-5,6,7,27-tetrahydroxy-1-oxowitha-2,24-dien-27-O-β-D-glucopyranoside (1), (5α,6β,7α,22R)-5,6,7,27-tetrahydroxy-1-oxowitha-2,24-dien-27-O-β-D-glucopyranoside (2), (5α,6β,7α,12β,22R)-5,6,7,12,27-pentahydroxy-1-oxowitha-2,24-dien-27-O-β-D-glucopyranoside (3), and (5α,6β,22R)-5,6,27-trihydroxy-1-oxowitha-2,24-dien-27-O-β-D-glucopyranoside (4) on the basis of chemical and physicochemical evidence.
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KEYWORD
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Datura metel L., Solananceae, Withanolide glucosides, Baimantuoluosides
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